Reply by Dr. David M. Eddy: Malignant Melanoma

Dr. David Rimm

Dr. David Rimm, MD PhD, is a professor of Pathology at the Yale University School of Medicine specializing in developing quantitative, diagnostic techniques. His lab recently engineered a fluorescence-based algorithm, Automated Quantitative Analysis (AQUA), to analyze tissue microarrays in the hope of moving toward personalized medicine and diagnoses.

Dr. Wallace and Dr. Stone reply.

Reply to Dr. Weiskirchen.

TO THE EDITOR: We would like to thank Dr. Weiskirchen (5) for his interest in our recent publication (3). As we mentioned in the DISCUSSION and as pointed out by Dr. Weiskirchen, the absence of protein data in our adenovirus model represents a limitation of our study. Regarding the RNA expression, we also expected to find a greater difference in ccn1/cyr61 gene expression in the mice instilled ...

Reply to Dr. Chacko.

TO THE EDITOR: We thank Dr. Chacko (2) for reading our recently published article (3) and providing comments. In her first point, she makes the argument that moderate intensity exercise 45 min after a meal improves postprandial glycemia more effectively compared with higher intensity exercise. This statement was made based on findings from three different studies consisting of three different p...

Primary duodenal malignant melanoma: A case report

Background: Melanoma is a neoplasm derived commonly from melanocytic cells of skin. Although coetaneous presentation of malignant melanoma is easily recognizable, the presentation of melanoma in other organs is so confusing. In particular, when it metastasizes to other organs, many bizarre figures and unusual organs may be involved. In this report, we present a case of primary duodenal malignan...